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JTE-907 is a selective high-affinity inverse agonist for the cannabinoid CB2 receptor. It is known to increase forskolin-stimulated cAMP production in cells expressing human and mouse CB2 receptors. This compound has been studied for its potential in treating atopic dermatitis and has shown to suppress itch-associated responses in animal models without causing significant side effects like weight loss.

Additionally, JTE-907 acts as an antagonist for the cannabinoid CB1 receptor, but with much lower potency compared to its activity on CB2 receptors. This dual activity has made it useful in research exploring the roles of these receptors in conditions like neurodegenerative disorders and inflammatory responses. For instance, studies have shown that blocking CB2 receptors with JTE-907 can inhibit anxiety-like behaviors in rats under stress, suggesting potential applications in anxiety treatment research.

The compound was originally developed by Japan Tobacco and is often used in research for understanding the pharmacological modulation of cannabinoid receptors in various diseases and conditions.

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